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Viagra®
(Sildenafil Citrate) is used as a therapy for erectile dysfunction, and
is administered orally. Sildenafil is a selective inhibitor of cyclic
guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Adverse Event |
Percentage of Patients |
Reporting Event |
|
|
VIAGRA N=734 |
PLACEBO N=725 |
| Headache |
16% |
4% |
| Flushing |
10% |
1% |
| Dyspepsia |
7% |
2% |
| Nasal Congestion |
4% |
2% |
| Urinary Tract Infection |
3% |
2% |
| Abnormal Vision |
3% |
0% |
| Diarrhea |
3% |
1% |
| Dizziness |
2% |
1% |
| Rash |
2% |
1% |
Apart from the above, Viagra® has also shown
interactions with many other drugs.
What other drugs are known to affect Sildenafil?
•Sildenafil must not be taken if a nitrate
drug is also being taken for angina or other heart problems. These
nitrates include:
• nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid,
Minitran, Deponit, Transderm-Nitro),
• isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and
• isosorbide mononitrate (Imdur, ISMO, Monoket), or
• recreational drugs such as amyl nitrate or nitrite ("poppers")
• Your doctor must be notified before you use
Sildenafil, if you are on any of the following medication:
• bosentan (Tracleer);
• cimetidine (Tagamet, Tagamet HB);
• an antibiotic such as erythromycin (E-Mycin, Eryc, Ery-Tab) or
clarithromycin (Biaxin);
• doxazosin (Cardura), prazosin (Minipress), Terazosin (Hytrin);
• HIV medicines such as amprenavir (Agenerase), tipranavir (Aptivus),
darunavir (Prezista), efavirenz (Sustiva), nevirapine (Viramune),
indinavir (Crixivan), saquinavir (Invirase, Fortovase), lopinavir/
ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir (Norvir),
atazanavir (Reyataz), or nelfinavir (Viracept);
• an antifungal medication such as itraconazole (Sporanox) or
ketoconazole (Nizoral);
• carbamazepine (Tegretol), phenobarbital (Luminal), or phenytoin
(Dilantin); or
• Rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).
• If any of the above medicines are being taken, you
might require appropriate dosage adjustments or special tests to be
taken or you might just not be allowed to use Sildenafil at all.
However, that’s not the end of the list. There might be others that
affect Sildenafil too. It is safest to let your doctor know all details
of your medications, both prescribed and over-the-counter. This includes
vitamins, minerals, herbal products, and drugs prescribed by other
doctors. New medication must not be started unless your doctor is
notified of the same.
Cialis®
(tadalafil) is also a selective inhibitor of cyclic
guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5),
and used in the treatment of ED.
Like Viagra, Cialis too has an enormous list of side effects as
listed below:
| |
Placebo |
Tadalafil 5 mg |
Tadalafil 10 mg |
Tadalafil 20 mg |
| Adverse Event |
(N=476) |
(N=151) |
(N=394) |
(N=635) |
| Headache |
5% |
11% |
11% |
15% |
| Dyspepsia |
1% |
4% |
8% |
10% |
| Back Pain |
3% |
3% |
5% |
6% |
| Myalgia |
1% |
1% |
4% |
3% |
| Nasal congestion |
1% |
2% |
3% |
3% |
| Flushing* |
1% |
2% |
3% |
3% |
| Pain in limb |
1% |
1% |
3% |
3% |
The following are the drug interactions caused
with Cialis:
• cimetidine (Tagamet, Tagamet HB);
• erythromycin (E-Mycin, Eryc, Ery-Tab) or clarithromycin (Biaxin);
• doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin);
• HIV medicines such as amprenavir (Agenerase), tipranavir (Aptivus),
darunavir (Prezista), efavirenz (Sustiva), nevirapine (Viramune),
indinavir (Crixivan), saquinavir (Invirase, Fortovase),
lopinavir/ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir
(Norvir), atazanavir (Reyataz), or nelfinavir (Viracept);
• itraconazole (Sporanox) or ketoconazole (Nizoral);
• carbamazepine (Tegretol), phenobarbital (Luminal), or phenytoin
(Dilantin); or
• rifampin (Rifadin, Rimactane).
*Source, drugs.com
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